Personalized Respiratory Medicine: Exploring the Horizon, Addressing the Issues Summary of a BRN-AJRCCM Workshop Held in Barcelona on June 12, 2014

被引：60

作者：

Agusti, Alvar ^{[1
,2
]}

Anto, Josep Maria ^{[3
]}

Auffray, Charles ^{[4
]}

Barbe, Ferran ^{[2
,5
]}

Barreiro, Esther ^{[2
,6
]}

Dorca, Jordi ^{[2
,7
]}

Escarrabill, Joan ^{[1
]}

Faner, Rosa ^{[1
,2
]}

Furlong, Laura I. ^{[8
]}

Garcia-Aymerich, Judith ^{[3
]}

Gea, Joaquim ^{[2
,6
]}

Lindmark, Bertil ^{[9
]}

Monso, Eduard ^{[2
,10
]}

Plaza, Vicente ^{[11
]}

Puhan, Milo A.

Roca, Josep ^{[1
,2
,12
]}

Ruiz-Manzano, Juan ^{[2
,12
,13
]}

Sampietro-Colom, Laura ^{[1
]}

Sanz, Ferran ^{[8
]}

Serrano, Luis ^{[14
,15
]}

Sharpe, James ^{[14
,15
]}

Sibila, Oriol

Silverman, Edwin K. ^{[16
]}

Sterk, Peter J. ^{[17
]}

Sznajder, Jacob I. ^{[18
]}

机构：

[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, E-08007 Barcelona, Spain

[2] CIBERES, Madrid, Spain

[3] Univ Pompeu Fabra, Ctr Invest Biomed Red Epidemiol & Salud Publ, Hosp Mar Med Res Inst, Ctr Res Environm Epidemiol, Barcelona, Spain

[4] European Inst Syst Biol & Med, Lyon, France

[5] Inst Rec Biomed Lleida, Lleida, Spain

[6] Univ Pompeu Fabra, CEXS, Hosp Mar Hosp Mar Med Res Inst, Dept Pulmonol, Barcelona, Spain

[7] Univ Barcelona, Hosp Univ Bellvitge, El Inst Invest Biomed Bellvitge, Barcelona, Spain

[8] Univ Pompeu Fabra, Hosp Mar, Med Res Inst, Res Programme Biomed Informat, Barcelona, Spain

[9] Lab Almirall, Barcelona, Spain

[10] Hosp Univ Parc Tauli, Sabadell, Spain

[11] Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, IIB Sant Pau, E-08193 Barcelona, Spain

[12] Univ Zurich, Biostat & Prevent Inst, Zurich, Switzerland

[13] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Badalona, Spain

[14] Ctr Genom Regulat, Ctr Genom Regulat Syst Biol, European Mol Biol Lab, Res Unit, Barcelona, Spain

[15] Inst Catalana Rec & Estudis Avancats, Barcelona, Spain

[16] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA

[17] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[18] Northwestern Univ, Chicago, IL 60611 USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2015年 / 191卷 / 04期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; OMICS-BASED PREDICTORS; HEALTH-CARE; SYSTEMS BIOLOGY; NETWORK MEDICINE; KNOWLEDGE MANAGEMENT; INTEGRATED CARE; GENE-EXPRESSION; DISEASE; LUNG;

D O I：

10.1164/rccm.201410-1935PP

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This Pulmonary Perspective summarizes the content and main conclusions of an international workshop on personalized respiratory medicine coorganized by the Barcelona Respiratory Network (www.brn.cat) and the AJRCCM in June 2014. It discusses (1) its definition and historical, social, legal, and ethical aspects; (2) the view from different disciplines, including basic science, epidemiology, bioinformatics, and network/systems medicine; (3) the bottlenecks and opportunities identified by some currently ongoing projects; and (4) the implications for the individual, the healthcare system and the pharmaceutical industry. The authors hope that, although it is not a systematic review on the subject, this document can be a useful reference for researchers, clinicians, healthcare managers, policy-makers, and industry parties interested in personalized respiratory medicine.

引用

页码：391 / 401

页数：11

共 100 条

[1] Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers [J].

Adamski, Jakub ;

Godman, Brian ;

Ofierska-Sujkowska, Gabriella ;

Osinska, Boguslawa ;

Herholz, Harald ;

Wendykowska, Kamila ;

Laius, Ott ;

Jan, Saira ;

Sermet, Catherine ;

Zara, Corrine ;

Kalaba, Marija ;

Gustafsson, Roland ;

Garuoliene, Kristina ;

Haycox, Alan ;

Garattini, Silvio ;

Gustafsson, Lars L. .

BMC HEALTH SERVICES RESEARCH, 2010, 10

[2] The path to personalised medicine in COPD [J].

Agusti, Alvar .

THORAX, 2014, 69 (09) :857-864

[3] The COPD control panel: towards personalised medicine in COPD [J].

Agusti, Alvar ;

MacNee, William .

THORAX, 2013, 68 (07) :687-690

[4] Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype [J].

Agusti, Alvar ;

Edwards, Lisa D. ;

Rennard, Stephen I. ;

MacNee, William ;

Tal-Singer, Ruth ;

Miller, Bruce E. ;

Vestbo, Jorgen ;

Lomas, David A. ;

Calverley, Peter M. A. ;

Wouters, Emiel ;

Crim, Courtney ;

Yates, Julie C. ;

Silverman, Edwin K. ;

Coxson, Harvey O. ;

Bakke, Per ;

Mayer, Ruth J. ;

Celli, Bartolome .

PLOS ONE, 2012, 7 (05)

[5]

Annas GJ, 2014, NEW ENGL J MED, V370, P985, DOI [10.1056/NEJMp1316367, 10.1056/NEJMc1404692]

[6] Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar [J].

Anto, Josep M. ;

Pinart, Mariona ;

Akdis, Muebeccel ;

Auffray, Charles ;

Bachert, Claus ;

Basagana, Xavier ;

Carlsen, Kai-Hakon ;

Guerra, Stefano ;

von Hertzen, Leena ;

Illi, Sabina ;

Kauffmann, Francine ;

Keil, Thomas ;

Kiley, James P. ;

Koppelman, Gerard H. ;

Lupinek, Christian ;

Martinez, Fernando D. ;

Nawijn, Martijn C. ;

Postma, Dirkje S. ;

Siroux, Valerie ;

Smit, Henriette A. ;

Sterk, Peter J. ;

Sunyer, Jordi ;

Valenta, Rudolf ;

Valverde, Sergio ;

Akdis, Cezmi A. ;

Annesi-Maesano, Isabella ;

Ballester, Ferran ;

Benet, Marta ;

Cambon-Thomsen, Anne ;

Chatzi, Leda ;

Coquet, Jonathan ;

Demoly, Pascal ;

Gan, Weiniu ;

Garcia-Aymerich, Judith ;

Gimeno-Santos, Elena ;

Guihenneuc-Jouyaux, Chantal ;

Haahtela, Tari ;

Heinrich, Joachim ;

Herr, Marie ;

Hohmann, Cynthia ;

Jacquemin, Benedicte ;

Just, Jocelyne ;

Kerkhof, Marjan ;

Kogevinas, Manolis ;

Kowalski, Marek L. ;

Lambrecht, Bart N. ;

Lau, Susanne ;

Carlsen, Karin C. Lodrup ;

Maier, Dieter ;

Momas, Isabelle .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (04) :943-U421

[7] Telomerase mutations in families with idiopathic pulmonary fibrosis [J].

Armanios, Mary Y. ;

Chen, Julian J. -L. ;

Cogan, Joy D. ;

Alder, Jonathan K. ;

Ingersoll, Roxann G. ;

Markin, Cheryl ;

Lawson, William E. ;

Xie, Mingyi ;

Vulto, Irma ;

Phillips, John A., III ;

Lansdorp, Peter M. ;

Greider, Carol W. ;

Loyd, James E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) :1317-1326

[8] Editorial: Systems biology and personalized medicine - the future is now [J].

Auffray, Charles ;

Hood, Leroy .

BIOTECHNOLOGY JOURNAL, 2012, 7 (08) :938-939

[9] An Integrative Systems Biology Approach to Understanding Pulmonary Diseases [J].

Auffray, Charles ;

Adcock, Ian M. ;

Chung, Kian Fan ;

Djukanovic, Ratko ;

Pison, Christophe ;

Sterk, Peter J. .

CHEST, 2010, 137 (06) :1410-1416

[10] Systems medicine: the future of medical genomics and healthcare [J].

Auffray, Charles ;

Chen, Zhu ;

Hood, Leroy .

GENOME MEDICINE, 2009, 1

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