In-vitro anti-cancer activity of shape controlled silver nanoparticles (AgNPs) in various organ specific cell lines

This paper introduced a green technology for the synthesis of a shape controlled silver nanoparticles (AgNPs) through a mutual interaction of indigenous polysaccharides, Acacia nilotica or natural gum (NG) and tamarind kernel powder or TIT under a specified condition. The resultant particles were characterized using spectroscopy, microscopy and light scattering techniques which demonstrated the generation of a spherical nanoparticles with an average hydrodynamic size ranging between 10 nm to 78 nm (from light scattering experiment). The AgNPs were fairly stable. On in vitro application into different organ specific cancer cell lines e.g. cervical cancer or hela, lung cancer or A549 and mice macrophage or Raw 264.7, it elucidated a dose responsive antitumor cum antioxidant activity with high selectivity which might be an indication for its potential use in anticancer therapy. (C) 2017 Elsevier B.V. All rights reserved.