Real-time imaging of lymphocytes in vivo

被引：69
作者：
Cahalan, MD [1 ]
Parker, I
Wei, SH
Miller, MJ
机构：
[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(03)00079-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
New preparations, fluorescent probes and imaging techniques are providing the means to observe the behavior of cells in the tissue environment of lymphoid organs. In particular, when combined with two-photon laser microscopy, intravital imaging of surgically exposed lymph nodes provides a unique view of lymphocyte migration and antigen presentation as it occurs within the living animal. The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients.
引用
收藏
页码：372 / 377
页数：6
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