Cellular Sources of Tenascin-C in Canine Mammary Carcinomas

被引：11
作者：
Yoshimura, H. [1 ,2 ,3 ]
Michishita, M. [1 ]
Ohkusu-Tsukada, K. [1 ]
Matsuda, Y. [2 ,3 ]
Ishiwata, T. [2 ,3 ]
Naito, Z. [2 ,3 ]
Takahashi, K. [1 ]
机构：
[1] Nippon Vet & Life Sci Univ, Dept Vet Pathol, Tokyo 1808602, Japan
[2] Nippon Med Sch, Dept Pathol, Tokyo 113, Japan
[3] Nippon Med Sch, Dept Integrat Oncol Pathol, Tokyo 113, Japan
来源：
VETERINARY PATHOLOGY | 2015年 / 52卷 / 01期
关键词：
dogs; immunohistochemistry; in situ hybridization; mammary tumor; mammary carcinoma; myoepithelial cell; myofibroblast; tenascin-C; STROMAL MYOFIBROBLASTS; TUMORS; EXPRESSION; COMPONENT; CANCER; CELLS;
D O I：
10.1177/0300985814522817
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Tenascin-C (Tn-C) is an extracellular matrix glycoprotein implicated in the progression of several human cancers. In canine mammary carcinomas, accumulation of Tn-C has been recognized in 3 different areas: regions of proliferating myoepithelial cells in complex carcinoma, basement membrane zone in low-grade simple carcinoma, and reactive stroma in high-grade simple carcinoma. To identify the Tn-C synthesizing cells in these areas, we utilized double-labeling immunohistochemistry, branched DNA in situ hybridization, and in situ hybridization-immunohistochemistry double-labeling techniques. In complex carcinomas, Tn-C was generated by proliferating myoepithelial cells. Tn-C in low-grade simple carcinomas was also derived from myoepithelial cells existing as a basal monolayer. However, stromal Tn-C in high-grade carcinomas was mainly synthesized by fibroblasts/myofibroblasts, similar to human breast cancer. Thus, the origin of Tn-C in canine mammary carcinomas differs between low- and high-grade malignancies. The role of myoepithelial cell-generated Tn-C is not yet understood.
引用
收藏
页码：92 / 96
页数：5
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