Psoriasis and Cardiovascular Diseases: An Immune-Mediated Cross Talk?

被引：23
作者：
Orlando, Gloria [1 ,2 ]
Molon, Barbara [2 ,3 ]
Viola, Antonella [2 ,3 ]
Alaibac, Mauro [1 ]
Angioni, Roberta [2 ,3 ]
Piaserico, Stefano [1 ]
机构：
[1] Univ Padua, Dept Med DIMED, Unit Dermatol, Padua, Italy
[2] Univ Padua, Dept Biomed Sci DSB, Padua, Italy
[3] Citta Speranza IRP, Ist Ric Pediat, Padua, Italy
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
英国科研创新办公室;
关键词：
psoriasis; cytokines; endothelial dysfunction (ED); cardiovascular diseases; inflammation; AORTIC VASCULAR INFLAMMATION; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; INHIBITOR THERAPY; PLAQUE PSORIASIS; YOUNG-PATIENTS; ALPHA THERAPY; RISK;
D O I：
10.3389/fimmu.2022.868277
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Psoriasis is a chronic immune-mediated inflammatory skin disease, characterized by well-demarcated scaly, erythematous, infiltrated plaques. The cutaneous-to-systemic expansion of the inflammation in psoriasis leads to the concept of "psoriatic march" or "inflammatory skin march". Accordingly, psoriasis is thought to be a systemic inflammatory disease associated with numerous comorbidities. Indeed, it's currently considered an independent risk factor for cardiovascular diseases. Here, we discuss the current knowledge on TNF-alpha and IL-23/IL-17 mediated pathways linking the psoriatic plaque to the cardiovascular compartment. We further argue the possible involvement of the endothelial compartment in the psoriatic plaque- cardiovascular system crosstalk.
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