The emerging roles of YAP and TAZ in cancer

被引：950

作者：

Moroishi, Toshiro ^{[1
,2
]}

Hansen, Carsten Gram ^{[1
,2
]}

Guan, Kun-Liang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 02期

基金：

美国国家卫生研究院; 日本学术振兴会;

关键词：

HIPPO SIGNALING PATHWAY; MUTATIONAL LANDSCAPE; GROWTH-CONTROL; TISSUE-GROWTH; CELL-GROWTH; DNA-DAMAGE; TUMORIGENESIS; ACTIVATION; COMPLEX; PHOSPHORYLATION;

D O I：

10.1038/nrc3876

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

引用

页码：73 / 79

页数：7

共 65 条

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