Mesoporous silica coatings for cephalosporin active release at the bone-implant interface

被引：17

作者：

Radulescu, Dragos ^{[1
]}

Voicu, Georgeta ^{[2
]}

Oprea, Alexandra Elena ^{[2
]}

Andronescu, Ecaterina ^{[2
]}

Grumezescu, Valentina ^{[2
,3
]}

Holban, Alina Maria ^{[2
,4
,5
]}

Vasile, Bogdan Stefan ^{[2
]}

Surdu, Adrian Vasile ^{[2
]}

Grumezescu, Alexandru Mihai ^{[2
]}

Socol, Gabriel

Mogoanta, Laurentiu ^{[6
]}

Mogosanu, George Dan ^{[7
]}

Balaure, Paul Catalin ^{[8
]}

Radulescu, Radu ^{[1
]}

Chifiriuc, Mariana Carmen ^{[4
,5
]}

机构：

[1] Bucharest Univ Hosp, Dept Orthoped & Traumatol, 169 Splaiul Independentei, Bucharest 050098, Romania

[2] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Sci & Engn Oxide Mat & Nanomat, 1-7 Polizu St, Bucharest 011061, Romania

[3] Natl Inst Lasers Plasma & Radiat Phys, Lasers Dept, POB MG-36, Bucharest, Romania

[4] Univ Bucharest, Fac Biol, Dept Microbiol & Immunol, 1-3 Portocalelor Lane, Bucharest, Romania

[5] Univ Bucharest, Res Inst, Bd Mihail Kogalniceanu 36-46, Bucharest 050107, Romania

[6] Univ Med & Pharm Craiova, Res Ctr Microscop Morphol & Immunol, 2 Petru Rares St, Craiova 200349, Romania

[7] Univ Med & Pharm Craiova, Fac Pharm, Dept Pharmacognosy & Phytotherapy, 2 Petru Rares St, Craiova 200349, Romania

[8] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Organ Chem Costin Nenitescu, 1-7 Polizu St, Bucharest 011061, Romania

来源：

APPLIED SURFACE SCIENCE | 2016年 / 374卷

关键词：

Zinforo; Escherichia coli; Antimicrobial coatings; Drug controlled release; Biodistribution; PULSED-LASER EVAPORATION; THIN-FILMS; DRUG-DELIVERY; DEPOSITION; NANOPARTICLES; ANTIBIOTICS; BIOFILMS; RESISTANCE; ADHESION; CATALYST;

D O I：

10.1016/j.apsusc.2015.10.183

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, we investigated the potential of MAPLE-deposited coatings mesoporous silica nanoparticles (MSNs) to release Zinforo (ceftarolinum fosmil) in biologically active form. The MSNs were prepared by using a classic procedure with cetyltrimethylammonium bromide as sacrificial template and tetraethylorthosilicate as the monomer. The Brunauer-Emmett-Teller (BET) and transmission electron microscopy (TEM) analyses revealed network-forming granules with diameters under 100 nm and an average pore diameter of 2.33 nm. The deposited films were characterized by SEM, TEM, XRD and IR. Microbiological analyses performed on ceftaroline-loaded films demonstrated that the antibiotic was released in an active form, decreasing the microbial adherence rate and colonization of the surface. Moreover, the in vitro and in vivo assays proved the excellent biodistribution and biocompatibility of the prepared systems. Our results suggest that the obtained bioactive coatings possess a significant potential for the design of drug delivery systems and antibacterial medical-use surfaces, with great applications in bone implantology. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：165 / 171

页数：7

共 33 条

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