Roles of β- and α2-Adrenoceptors Within the Central Nucleus of the Amygdala in the Visceral Pain-Induced Aversion in Rats

被引：11

作者：

Deyama, Satoshi ^{[1
,2
]}

Takishita, Azusa ^{[2
]}

Tanimoto, Sachi ^{[2
]}

Ide, Soichiro ^{[1
]}

Nakagawa, Takayuki ^{[2
]}

Satoh, Masamichi ^{[3
]}

Minami, Masabumi ^{[1
]}

机构：

[1] Hokkaido Univ, Dept Pharmacol, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Kyoto Univ, Dept Mol Pharmacol, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan

[3] Yasuda Womens Univ, Dept Pharm, Hiroshima 7310153, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 114卷 / 01期

关键词：

amygdala; emotion; visceral pain; NEGATIVE AFFECTIVE COMPONENT; VENTRAL BED NUCLEUS; STRIA TERMINALIS; ACTIVATION; TRANSMISSION; INVOLVEMENT; MORPHINE;

D O I：

10.1254/jphs.10139SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the roles of beta- and alpha(2)-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol, a beta-adrenoceptor antagonist, or clonidine, an alpha(2)-adrenoceptor agonist, without reducing writhing behaviors. These data suggest a pivotal role of intra-CeA adrenoceptors in the negative affective, but not sensory, component of visceral pain.

引用

页码：123 / 126

页数：4

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