Z-Selective intramolecular Horner-Wadsworth-Emmons reaction for the synthesis of macrocyclic alkenes

被引：11

作者：

Ando, Kaori ^{[1
]}

Sato, Kaori ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Chem, Gifu 5011193, Japan

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 12期

关键词：

Z-UNSATURATED ESTERS; ETHYL (DIARYLPHOSPHONO)ACETATES; ANISOMELIC ACID; OLEFINATION; ALDEHYDES; STEREOCHEMISTRY; CYCLIZATION; EFFICIENT; REAGENTS; BASE;

D O I：

10.1016/j.tetlet.2011.01.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Z-selective intramolecular Horner-Wadsworth-Emmons reaction of the substrates 7-12 (RO)(2)P(O)CHR'CO(2)Et (R' = (CH(2))(n)CHO) (R = Ph or o-tBuC(6)H(4)) gives the 13-18-membered cyclic alkenes selectively (up to Z:E = 97:3) in good yields using NaH in THF under high dilution conditions. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：1284 / 1287

页数：4

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