Innovation for hepatotoxicity in vitro research models: A review

被引：17

作者：

Han, Weijia ^{[1
,2
]}

Wu, Qiao ^{[1
,2
]}

Zhang, Xiaohui ^{[1
,2
]}

Duan, Zhongping ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Youan Hosp, Artificial Liver Ctr, Beijing 100069, Peoples R China

[2] Beijing Key Lab Liver Failure, Artificial Liver Treatment & Res, Beijing, Peoples R China

来源：

JOURNAL OF APPLIED TOXICOLOGY | 2019年 / 39卷 / 01期

基金：

国家重点研发计划;

关键词：

3D; co-culture; hepatotoxicity; innovation; research in vitro models; PLURIPOTENT STEM-CELLS; HEPATOCYTE-LIKE CELLS; ON-A-CHIP; METABOLICALLY FUNCTIONING HEPATOCYTES; PEROXISOMAL ENZYME-ACTIVITIES; NONPARENCHYMAL LIVER-CELLS; NUCLEAR FACTOR 6; EXTRACELLULAR-MATRIX; DRUG-METABOLISM; GENE-EXPRESSION;

D O I：

10.1002/jat.3711

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Many categories of drugs can induce hepatotoxicity, so improving the prediction of toxic drugs is important. In vitro models using human hepatocytes are more accurate than in vivo animal models. Good in vitro models require an abundance of metabolic enzyme activities and normal cellular polarity. However, none of the in vitro models can completely simulate hepatocytes in the human body. There are two ways to overcome this limitation: enhancing the metabolic function of hepatocytes and changing the cultural environment. In this review, we summarize the current state of research, including the main characteristics of in vitro models and their limitations, as well as improved technology and developmental prospects. We hope that this review provides some new ideas for hepatotoxicity research.

引用

页码：146 / 162

页数：17

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