Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum

被引：19

作者：

Choodej, Siwattra ^{[1
]}

Teerawatananond, Thapong ^{[2
]}

Mitsunaga, Tohru ^{[1
]}

Pudhom, Khanitha ^{[3
]}

机构：

[1] Gifu Univ, United Grad Sch Agr Sci, 1-1 Yanagido, Gifu 5011193, Japan

[2] Valaya Alongkorn Rajabhat Univ Royal Patronage, Fac Sci & Technol, Pathum Thani 13138, Thailand

[3] Chulalongkorn Univ, Dept Chem, Fac Sci, Bangkok 10330, Thailand

来源：

MARINE DRUGS | 2016年 / 14卷 / 07期

关键词：

chamigrane; sesquiterpene; endophytic fungus; cytotoxic; NORSESQUITERPENE PEROXIDES; RED ALGA; A-F; DERIVATIVES; SPIROBISNAPHTHALENES; ENDOPEROXIDES; METABOLITES;

D O I：

10.3390/md14070132

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new chamigrane sesquiterpenes, merulinols A-F (1-6), and four known metabolites (7-10) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC50 values of 35.0 and 25.3 mu M, respectively.

引用

页数：9

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