A Meta-Analysis of the Risk Factors of Persistent Pulmonary Hypertension in Newborns

被引：7

作者：

Zhou, Ran ^{[1
]}

Zheng, You-Ning ^{[1
]}

Zhang, Xin-Ying ^{[1
]}

Cheng, Ya-Ying ^{[1
]}

机构：

[1] HeBei Gen Hosp, Dept Pediat, Shijiazhuang, Hebei, Peoples R China

来源：

FRONTIERS IN PEDIATRICS | 2021年 / 9卷

关键词：

newborn; pulmonary hypertension; risk factors; case control study; meta-analysis; SEROTONIN-REUPTAKE INHIBITORS; MATERNAL USE; PREGNANCY;

D O I：

10.3389/fped.2021.659137

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: To determine the risk factors of persistent pulmonary hypertension of the newborn using a meta-analysis method and provide a reference for its clinical prevention and treatment. Methods: A meta-analysis was performed by searching the PubMed, Embase, Cochrane Library, China Biology Medicine Disc, Wanfang, and Chinese VIP journal databases, as well as the China National Knowledge Infrastructure. Results: A total of 22 references were included in the meta-analysis; the cumulative medical records comprised 7,937 cases, and 2,613,072 control cases were included. A total of 12 related risk factors were included (7 were associated with pregnant women and 5 were associated with newborns). Conclusion: Among the 12 associated risk factors included, the three most important and their combined odds ratio values and 95% CI were as follows: (1) pregnant women smoking, 4.85 (1.98-11.9) during pregnancy; (2) gestational weeks < 37, 4.34 (1.64-11.5); (3) perinatal asphyxia, 3.9 (2.87-5.31).

引用

页数：6

共 32 条

[1] Maternal Use of Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn
Alwan, S.
Bandoli, G.
Chambers, C. D.
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2016, 100 (01) : 34 - 41
[2] Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn
Andrade, Susan E.
McPhillips, Heather
Loren, David
Raebel, Marsha A.
Lane, Kimberly
Livingston, James
Boudreau, Denise M.
Smith, David H.
Davis, Robert L.
Willy, Mary E.
Platt, Richard
[J]. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2009, 18 (03) : 246 - 252
[3] Araujo Orlei Ribeiro de, 2008, Rev Bras Ter Intensiva, V20, P394
[4] Bearer C, 1997, ENVIRON HEALTH PERSP, V105, P202
[5] SSRI and SNRI use during pregnancy and the risk of persistent pulmonary hypertension of the newborn
Berard, Anick
Sheehy, Odile
Zhao, Jin-Ping
Vinet, Evelyne
Bernatsky, Sasha
Abrahamowicz, Michal
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2017, 83 (05) : 1126 - 1133
[6] Cai WH., 2010, J OCCUP HEALTH, V16, P25
[7] Use of Selective Serotonin Reuptake Inhibitor Antidepressants in Pregnancy Does Carry Risks, but the Risks Are Small
Casper, Regina C.
[J]. JOURNAL OF NERVOUS AND MENTAL DISEASE, 2015, 203 (03) : 167 - 169
[8] Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
Chambers, CD
Hernandez-Diaz, S
Van Marter, LJ
Werler, MM
Louik, C
Jones, KL
Mitchell, AA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) : 579 - 587
[9] Du LL., 2016, GUANGXI MED, V38, P496, DOI [10.11675/j.issn.0253-4304.2016.04.14, DOI 10.11675/J.ISSN.0253-4304.2016.04.14]
[10] Risk factors for persistent pulmonary hypertension of the newborn
Hernandez-Diaz, Sonia
Van Marter, Linda J.
Werler, Martha M.
Louik, Carol
Mitchell, Allen A.
[J]. PEDIATRICS, 2007, 120 (02) : E272 - E282

← 1 2 3 4 →