Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease

被引：40

作者：

Amalric, Marianne ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, UMR 7291, Cognit Neurosci Lab, F-13331 Marseille, France

来源：

CURRENT OPINION IN PHARMACOLOGY | 2015年 / 20卷

关键词：

POSITIVE ALLOSTERIC MODULATOR; GROUP-III; BASAL-GANGLIA; RODENT MODELS; RAT MODEL; L-DOPA; INDUCED DYSKINESIA; BLOCKADE; DEFICITS; AGONIST;

D O I：

10.1016/j.coph.2014.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interplay between dopamine and glutamate in the basal ganglia regulate critical aspects of motor and cognitive behavior. Metabotropic glutamate (mGlu) receptors are key modulators of glutamatergic dysfunction in Parkinson's disease (PD). Preclinical evidence demonstrate that group I mGlu receptor antagonism and groups II and Ill mGlu receptor activation improve motor symptomatology of PD and decrease L-DOPA-induced dyskinesia by regulating excitatory and inhibitory transmission in the basal ganglia. Emotional and cognitive deficits are also observed in PD. Treatment of these symptoms is challenging and underscore the need for novel effective and well tolerated pharmacological treatments. This article will thus review the currently available knowledge regarding the therapeutic potential of targeting mGlu receptors to restore motor and nonmotor symptoms of PD.

引用

页码：29 / 34

页数：6

共 64 条

[1] A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design [J].

Acher, Francine C. ;

Selvam, Chelliah ;

Pin, Jean-Philippe ;

Goudet, Cyril ;

Bertrand, Hugues-Olivier .

NEUROPHARMACOLOGY, 2011, 60 (01) :102-107

[2] Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease [J].

Amalric, M. ;

Lopez, S. ;

Goudet, C. ;

Fisone, G. ;

Battaglia, G. ;

Nicoletti, F. ;

Pin, J. -P. ;

Acher, F. C. .

NEUROPHARMACOLOGY, 2013, 66 :53-64

[3]

[Anonymous], BIOL PSYCHIAT

[4] Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated [J].

Ayala, Jennifer E. ;

Niswender, Colleen M. ;

Luo, Qingwel ;

Banko, Jessica L. ;

Conn, P. Jeffrey .

NEUROPHARMACOLOGY, 2008, 54 (05) :804-814

[5] Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory [J].

Balschun, D. ;

Zuschratter, W. ;

Wetzel, W. .

NEUROSCIENCE, 2006, 142 (03) :691-702

[6] Immediate-early gene expression in structures outside the basal ganglia is associated to L-DOPA-induced dysldnesia [J].

Bastide, Matthieu F. ;

Dovero, Sandra ;

Charron, Giselle ;

Porras, Gregory ;

Gross, Christian E. ;

Fernagut, Pierre-Olivier ;

Bezard, Erwan .

NEUROBIOLOGY OF DISEASE, 2014, 62 :179-192

[7] Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice [J].

Battaglia, G ;

Busceti, CL ;

Molinaro, G ;

Biagioni, F ;

Storto, M ;

Fornai, F ;

Nicoletti, F ;

Bruno, V .

JOURNAL OF NEUROSCIENCE, 2004, 24 (04) :828-835

[8] Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia [J].

Bennouar, Khaled-Ezaheir ;

Uberti, Michelle A. ;

Melon, Christophe ;

Bacolod, Maria D. ;

Jimenez, Hermogenes N. ;

Cajina, Manuel ;

Goff, Lydia Kerkerian-Le ;

Doller, Dario ;

Gubellini, Paolo .

NEUROPHARMACOLOGY, 2013, 66 :158-169

[9] Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism [J].

Beurrier, Corinne ;

Lopez, Sebastien ;

Revy, Delphine ;

Selvam, Chelliah ;

Goudet, Cyril ;

Lherondel, Morgane ;

Gubellini, Paolo ;

Kerkerian-LeGoff, Lydia ;

Acher, Francine ;

Pin, Jean-Philippe ;

Amalric, Marianne .

FASEB JOURNAL, 2009, 23 (10) :3619-3628

[10] Cognitive Impairment and Dentate Gyrus Synaptic Dysfunction in Experimental Parkinsonism [J].

Bonito-Oliva, Alessandra ;

Pignatelli, Marco ;

Spigolon, Giada ;

Yoshitake, Takashi ;

Seiler, Stefanie ;

Longo, Francesco ;

Piccinin, Sonia ;

Kehr, Jan ;

Mercuri, Nicola B. ;

Nistico, Robert ;

Fisone, Gilberto .

BIOLOGICAL PSYCHIATRY, 2014, 75 (09) :701-710

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