Reversal of fludarabine induced testicular damage in a patient with chronic lymphocytic leukaemia (CLL), by suppression of pituitary-testicular axis using Gonadotrophin releasing hormone (GnRH)

被引：6

作者：

Chatterjee, R ^{[1
]}

Kottaridis, PD ^{[1
]}

McGarrigle, H ^{[1
]}

Goldstone, AH ^{[1
]}

机构：

[1] UCL Hosp, Dept Obstet & Gynaecol, Reprod Med Unit, London WC1E 6AU, England

来源：

LEUKEMIA & LYMPHOMA | 2001年 / 41卷 / 1-2期

关键词：

fludarabine; gonadotrophin releasing hormone; chronic lymphocytic leukaemia; pituitary-testicular axis;

D O I：

10.3109/10428190109057974

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe a case of a 47 year old man with CLL who was treated with 7 courses of fludarabine with simultaneous suppression or his pituitary-testicular axis (P-T) with Gonadotrophin releasing hormone (GnRH) and replacement treatment with testosterone. Despite initial gonadal damage as evident by endocrine and sperm studies. testicular recovery was observed 11 months post treatment. Although spontaneous recovery cannot be ruled out. continous treatment with GnRH and testosterone may play a crucial role protecting the gonads from the cytotoxic effects of the chemotherapeutic agents.

引用

页码：213 / 215

页数：3