Targeting Angiogenesis Taming the Medusa of Ovarian Cancer

被引：11

作者：

Dhani, Neesha C. ^{[1
,2
]}

Oza, Amit M. ^{[1
,3
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON, Canada

[2] Princess Margaret Canc Ctr, Div Med Oncol & Hematol, 700 Univ Ave,Suite 7-817, Toronto, ON M5G 1Z5, Canada

[3] Princess Margaret Canc Ctr, Div Med Oncol & Hematol, 700 Univ Ave,Suite 7-925, Toronto, ON M5G 1Z5, Canada

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 06期

关键词：

Angiogenesis; Ovarian cancer; Maintenance; Vascular endothelial growth factor (VEGF); Bevacizumab; PEGYLATED LIPOSOMAL DOXORUBICIN; RECURRENT EPITHELIAL OVARIAN; BEVACIZUMAB-CONTAINING THERAPY; RANDOMIZED PHASE-III; DOUBLE-BLIND; OPEN-LABEL; PRIMARY PERITONEAL; WEEKLY PACLITAXEL; TRIAL; CHEMOTHERAPY;

D O I：

10.1016/j.hoc.2018.07.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial ovarian cancer remains the most lethal gynecologic cancers with a 5-year survival rate of less than 50%. Cytotoxic combinations are associated with incremental toxicity, leading to interest in evaluating cytotoxic/biologic combinations with improved therapeutic ratios. Angiogenesis is critical to the normal physiology of the gynecologic tract and a novel drug target. Current data suggests antiangiogenics should be considered a critical component of epithelial ovarian cancer treatment. Given the serious adverse event of gastrointestinal perforation/fistula in advanced disease, priority should be given to front-line treatment. Active investigation continues in the development of novel combinations with other biologics.

引用

页码：1041 / +

页数：17

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