Chemical imaging and assessment of cadmium distribution in the human body

被引:77
作者
Egger, Alexander E. [1 ,2 ]
Grabmann, Gerlinde [1 ]
Gollmann-Tepekoeylue, Can [3 ,4 ]
Pechriggl, Elisabeth J. [4 ]
Artner, Christian [1 ]
Tuerkcan, Adrian [5 ]
Hartinger, Christian G. [1 ,6 ]
Fritsch, Helga [4 ]
Keppler, Bernhard K. [1 ]
Brenner, Erich [4 ]
Grimm, Michael [3 ]
Messner, Barbara [5 ]
Bernhard, David [3 ,7 ,8 ]
机构
[1] Univ Vienna, Inst Inorgan Chem, Vienna, Austria
[2] ADSI Austrian Drug Screening Inst GmbH, Innsbruck, Austria
[3] Med Univ Innsbruck, Univ Clin Cardiac Surg, Cardiac Surg Res Lab, Innsbruck, Austria
[4] Med Univ Innsbruck, Dept Anat Histol & Embryol, Div Clin & Funct Anat, Innsbruck, Austria
[5] Vienna Med Univ, Cardiac Surg Res Lab, Vienna, Austria
[6] Univ Auckland, Sch Chem Sci, Auckland, New Zealand
[7] Johannes Kepler Univ Linz, Ctr Med Res, Krankenhausstr 7a, A-4020 Linz, Austria
[8] Johannes Kepler Univ Linz, Med Fac, Inst Physiol & Pathophysiol, Div Pathophysiol, Linz, Austria
关键词
RISK-FACTOR; ZINC; METALS; ACCUMULATION; MECHANISMS; EXPOSURE; DONATION; BIOLOGY; TOBACCO; EUROPE;
D O I
10.1039/c9mt00178f
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The scientific interest in cadmium (Cd) as a human health damaging agent has significantly increased over the past decades. However, particularly the histological distribution of Cd in human tissues is still scarcely defined. Using inductively coupled plasma-mass spectrometry (ICP-MS), we determined the concentration of Cd in 40 different human tissues of four body donors and provided spatial information by elemental imaging on the microscopic distribution of Cd in 8 selected tissues by laser ablation (LA)-ICP-MS. ICP-MS results show that Cd concentrations differ by a factor of 20000 between different tissues. Apart from the well know deposits in kidney, bone, and liver, our study provides evidence that muscle and adipose tissue are underestimated Cd pools. For the first time, we present spatially resolved Cd distributions in a broad panel of human soft tissues. The defined histological structures are mirrored by sharp cut differences in Cd concentrations between neighboring tissue types, particularly in the rectum, testis, and kidneys. The spatial resolution of the Cd distribution at microscopic level visualized intratissue hot spots of Cd accumulation and is suggested as a powerful tool to elucidate metal based toxicity at histological level.
引用
收藏
页码:2010 / 2019
页数:10
相关论文
共 43 条
[1]   Cadmium accumulation in aortas of smokers [J].
Abu-Hayyeh, S ;
Sian, M ;
Jones, KG ;
Manuel, A ;
Powell, JT .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (05) :863-867
[2]   Partial Mediation by Cadmium Exposure of the Association Between Tobacco Smoking and Atherosclerotic Plaques in the Carotid Artery [J].
Andersson, Eva M. ;
Fagerberg, Bjorn ;
Sallsten, Gerd ;
Borne, Yan ;
Hedblad, Bo ;
Engstrom, Gunnar ;
Barregard, Lars .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2018, 187 (04) :806-816
[3]   Changes in bone mineral density 10 years after marked reduction of cadmium exposure in a Chinese population [J].
Chen, Xiao ;
Zhu, Guoying ;
Jin, Taiyi ;
Akesson, Agneta ;
Bergdahl, Ingvar A. ;
Lei, Lijian ;
Weng, Shifang ;
Liang, Yihuai .
ENVIRONMENTAL RESEARCH, 2009, 109 (07) :874-879
[4]   Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry ( LA-ICP-MS) [J].
Egger, Alexander E. ;
Kornauth, Christoph ;
Haslik, Werner ;
Hann, Stephan ;
Theiner, Sarah ;
Bayer, Guenther ;
Hartinger, Christian G. ;
Keppler, Bernhard K. ;
Pluschnigh, Ursula ;
Mader, Robert M. .
METALLOMICS, 2015, 7 (03) :508-515
[5]  
Elinder C.J.C., 1985, Cadmium Health, V1, P81
[6]  
FRIBERG L, 1959, AMA Arch Ind Health, V20, P401
[7]   Elemental bio-imaging of trace elements in teeth using laser ablation-inductively coupled plasma-mass spectrometry [J].
Hare, Dominic ;
Austin, Christine ;
Doble, Philip ;
Arora, Manish .
JOURNAL OF DENTISTRY, 2011, 39 (05) :397-403
[8]   Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution [J].
Hare, Dominic J. ;
New, Elizabeth J. ;
de Jonge, Martin D. ;
McColl, Gawain .
CHEMICAL SOCIETY REVIEWS, 2015, 44 (17) :5941-5958
[9]  
Hartwig A, 2013, METAL IONS LIFE SCI, V11, P491, DOI 10.1007/978-94-007-5179-8_15
[10]   Cadmium and Other Metal Levels in Autopsy Samples from a Cadmium-Polluted Area and Non-polluted Control Areas in Japan [J].
Hayashi, Chiyo ;
Koizumi, Naoko ;
Nishio, Hisahide ;
Koizumi, Naoru ;
Ikeda, Masayuki .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2012, 145 (01) :10-22