The role of innate immunity in asthma development and protection: Lessons from the environment

被引：17
作者：
Pivniouk, Vadim [1 ,2 ]
Gimenes Junior, Joao Antonio [1 ]
Honeker, Linnea K. [1 ]
Vercelli, Donata [1 ,2 ]
机构：
[1] Univ Arizona, Airway Dis Res Ctr, Asthma, Tucson, AZ USA
[2] Univ Arizona, Dept Cellular, Mol Med, Tucson, AZ USA
来源：
CLINICAL AND EXPERIMENTAL ALLERGY | 2020年 / 50卷 / 03期
关键词：
asthma; environment; farm effect; hygiene hypothesis; innate immunity; microbiome; TOLL-LIKE RECEPTORS; INDUCED AIRWAY HYPERREACTIVITY; GENOME-WIDE ASSOCIATION; GUT MICROBIOTA; ATOPIC SENSITIZATION; INFLAMMATORY RESPONSES; CHILDHOOD ASTHMA; DENDRITIC CELLS; EARLY-LIFE; FARM;
D O I：
10.1111/cea.13508
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.
引用
收藏
页码：282 / 290
页数：9
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