Associations of urinary phthalate metabolites with risk of papillary thyroid cancer

被引：35
作者：
Miao, Hongjian [1 ]
Liu, Xin [1 ,2 ]
Li, Jingguang [1 ]
Zhang, Lei [1 ]
Zhao, Yunfeng [1 ]
Liu, Shaoyan [3 ]
Ni, Song [3 ]
Wu, Yongning [1 ]
机构：
[1] China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China
[2] Wuhan Polytech Univ, Inst Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll, Dept Head & Neck Surg, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China
来源：
CHEMOSPHERE | 2020年 / 241卷
基金：
中国国家自然科学基金;
关键词：
Thyroid cancer; Case-control study; Phthalate; Urinary metabolites; EXPOSURE; SELENIUM; OBESITY; IODINE;
D O I：
10.1016/j.chemosphere.2019.125093
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Some studies have revealed thyrotoxicity of phthalates; however, associations of phthalate exposure with papillary thyroid cancer (PTC) remain unclear. We conducted a pair-matching case -control study of 111 PTC cases and 111 age- and sex-matched non-PTC controls to examine associations between urinary concentrations of phthalate metabolites and PTC. Phthalate metabolites were determined in fasting urine specimens by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS). After adjusting for potential confounders and other phthalate metabolites, the concentrations of the sum of di (2-ethylhexly) phthalate (DEHP) metabolites in urine were positively associated with PTC [odds ratio (OR) = 5.35; 95% confidence interval (CI): 1.61-17.83], suggesting the effect of phthalates exposure on PTC development. The findings require confirmation. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：6
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