A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

被引：4

作者：

Byg, Keld-Erik ^{[1
,2
,3
,4
,10
]}

Illes, Zsolt ^{[2
,3
,5
]}

Sejbaek, Tobias ^{[3
,6
,7
]}

Nguyen, Nina ^{[8
]}

Moller, Soren ^{[4
,9
]}

Lambertsen, Kate L. ^{[3
,5
]}

Nielsen, Helle H. ^{[2
,3
,5
]}

Ellingsen, Torkell ^{[1
,4
]}

机构：

[1] Odense Univ Hosp, Rheumatol Res Unit, JB Winsloewsvej 4, DK-5000 Odense, Denmark

[2] Odense Univ Hosp, Dept Neurol, JB Winsloewsvej 4, DK-5000 Odense, Denmark

[3] Univ Southern Denmark, Dept Clin Res, BRIDGE Brain Res Interdisciplinary Guided Excellen, JB Winsloewsvej 19, DK-5000 Odense, Denmark

[4] Univ Southern Denmark, Dept Clin Res, JB Winsloewsvej 19, DK-5000 Odense, Denmark

[5] Univ Southern Denmark, Inst Mol Med, Dept Neurobiol Res, JB Winsloewsvej 21, DK-5000 Odense, Denmark

[6] South West Jutland Univ Hosp Southern Denmark, Dept Neurol, Finsensgade 35, DK-6700 Esbjerg, Denmark

[7] Univ Southern Denmark, Dept Reg Hlth Res, JB Winsloewsvej 19, DK-5000 Odense, Denmark

[8] Odense Univ Hosp, Dept Radiol, JB Winsloewsvej 4, DK-5000 Odense, Denmark

[9] Odense Univ Hosp, Open Patient data Explorat Network, JB Winsloewsvej 9a, DK-5000 Odense, Denmark

[10] Univ Southern Denmark, Odense Univ Hosp, Dept Rheumatol, Rheumatol Res Unit, J B Win Sloewsvej 4, DK-5000 Odense, Denmark

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 369卷

关键词：

Neurosarcoidosis; Treatment; MRI; mRS; SDMT; FAS; DIGIT MODALITIES TEST; QUALITY-OF-LIFE; EVERYDAY COGNITIVE FAILURE; FATIGUE ASSESSMENT SCALE; LONG-TERM OUTCOMES; CLINICAL-MANIFESTATIONS; DEPRESSIVE SYMPTOMS; INVENTORY-II; DOUBLE-BLIND; SARCOIDOSIS;

D O I：

10.1016/j.jneuroim.2022.577913

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

引用

页数：10

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