Antinociceptive Activity of the Leaf Essential Oil of Coleus aromaticus Benth

被引：0

作者：

Pandey, Rishabh D. ^{[1
]}

Singh, Akhilesh V. ^{[2
]}

Pandey, Awanish ^{[1
]}

Tripathi, Poonam ^{[1
]}

机构：

[1] Inst Technol & Management, Dept Pharm, Gorakhpur, Uttar Pradesh, India

[2] Dibrugarh Univ, Dept Pharmaceut Sci, Dibrugarh, Assam, India

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2010年 / 29卷 / 05期

关键词：

Antinociception; Coleus aromaticus Benth; Essential oil; Writhing test; Hotplate Test; EXTRACT; LEAVES; MICE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was undertaken to evaluate the possible antinociceptive effect of Coleus aromatieus Benth oil. The pain sensitivity was assessed by the acetic acid induced writhing and hotplate models in mice. The essential oil exhibited a significant reduction in acetic acid induced writhing response, a dose dependent increase in reaction time against thermal pain and a moderate motor impairment at analgesic doses and significant reduction in endurance time at higher dose on rotarod apparatus. These experimental results suggest that essential oil (250 and 500 mg/kg) produced analgesic effect in mice and may be a candidate for the development of pharmacological agents used in the pain management.

引用

页码：808 / 810

页数：3

共 13 条

[1] THE COMPOSITION OF THE ESSENTIAL OIL IN THE LEAVES OF COLEUS-AROMATICUS BENTHAM AND THEIR IMPORTANCE AS A COMPONENT OF THE SPECIES ANTIAPHTHOSAE PH-NED-ED-V [J].

BOS, R ;

HENDRIKS, H ;

VANOS, FHL .

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1983, 5 (04) :129-130

[2] Antiepileptic effect of Plectranthus amboinicus (lour.) Spreng. (french marjoram) [J].

Buznego, MT ;

Pérez-Saad, H .

REVISTA DE NEUROLOGIA, 1999, 29 (04) :388-389

[3] ANESTHETIC, HYPOTHERMIC, MYORELAXANT AND ANTICONVULSANT EFFECTS OF SYNTHETIC EUGENOL DERIVATIVES AND NATURAL ANALOGS [J].

DALLMEIER, K ;

CARLINI, EA .

PHARMACOLOGY, 1981, 22 (02) :113-127

[4]

Deena M. J., 2002, International Journal of Aromatherapy, V12, P105, DOI 10.1016/S0962-4562(02)00035-8

[5] In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae) [J].

Diniz Gurgel, Ana Pavla A. ;

da Silva, Jackeline G. ;

Grangeiro, Ana Ruth S. ;

Oliveira, Danielli C. ;

Lima, Cynthia M. P. ;

da Silva, Aldo C. P. ;

Oliveira, Rinalda A. G. ;

Souza, Ivone A. .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 125 (02) :361-363

[6]

DUARTE IDG, 1988, BRAZ J MED BIOL RES, V21, P341

[7]

Iyer S.R., 1995, INDIAN MED PLANTS, V5, P235

[8] Mast cell stabilization property of Coleus aromaticus leaf extract in rat peritoneal mast cells [J].

Kumar, A. ;

Elango, K. ;

Markanday, S. ;

Undhad, C. V. ;

Kotadiya, A. V. ;

Savaliya, B. M. ;

Vyas, D. N. ;

Datta, D. .

INDIAN JOURNAL OF PHARMACOLOGY, 2007, 39 (02) :119-120

[9] Activity-guided isolation and identification of free radical-scavenging components from an aqueous extract of Coleus aromaticus [J].

Kumaran, A. ;

Karunakaran, R. Joel .

FOOD CHEMISTRY, 2007, 100 (01) :356-361

[10] ASSESSMENT OF ANTINOCICEPTIVE DRUG EFFECTS IN THE PRESENCE OF IMPAIRED MOTOR-PERFORMANCE [J].

PLUMMER, JL ;

CMIELEWSKI, PL ;

GOURLAY, GK ;

OWEN, H ;

COUSINS, MJ .

JOURNAL OF PHARMACOLOGICAL METHODS, 1991, 26 (01) :79-87

← 1 2 →