One-Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of β-Carbolines and Other [c]-Fused Pyridines

被引：64

作者：

Dhiman, Seema ^{[1
]}

Mishra, Uttam K. ^{[1
]}

Ramasastry, S. S. V. ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sect 81, Manuali PO, Sas Nagar 140306, Punjab, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 27期

关键词：

azides; beta-carbolines; Lewis acids; relay catalysis; transition metals; ENANTIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; CASCADE; ALPHA; AZIDE; CYCLOISOMERIZATION; DERIVATIVES; EFFICIENT; ALCOHOLS; HYDROAMINATION;

D O I：

10.1002/anie.201600840

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A divergent strategy is presented for the synthesis of 1,3-di- and 1,3,4-trisubstituted beta-carbolines through an unprecedented one-pot triple-orthogonal-metal relay catalysis, and 1,3-disubstituted 4-hydroxy-b-carbolines through a one-pot bimetallic relay catalysis from readily accessible 3-(2-aminophenyl)-5-hexenyn-3-ols. These strategies were elaborated to enable the synthesis of benzofuro[2,3-c]pyridines, benzothieno[2,3-c]pyridines, and isoquinolines, which otherwise require multistep synthesis.

引用

收藏

页码：7737 / 7741

页数：5

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