Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review

被引：28

作者：

Tozzi, Rossella ^{[1
]}

Cipriani, Fiammetta ^{[2
]}

Masi, Davide ^{[2
]}

Basciani, Sabrina ^{[2
]}

Watanabe, Mikiko ^{[2
]}

Lubrano, Carla ^{[2
]}

Gnessi, Lucio ^{[2
]}

Mariani, Stefania ^{[2
]}

机构：

[1] Sapienza Univ Rome, Dept Mol Med, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Dept Expt Med, Sect Med Physiopathol Food Sci & Endocrinol, I-00161 Rome, Italy

来源：

NUTRIENTS | 2022年 / 14卷 / 15期

关键词：

SIRT1; ketone bodies; ketogenic diet; beta-OH-butyrate; obesity; epigenetic regulators; visceral fat; NAFLD; FATTY-ACID-METABOLISM; KETOGENIC DIET; ADIPOSE-TISSUE; BETA-HYDROXYBUTYRATE; HEPATIC STEATOSIS; CIRCULATING SIRT1; OXIDATIVE STRESS; GENE-EXPRESSION; LIVER-DISEASE; RESOLVIN D1;

D O I：

10.3390/nu14153145

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology, and cancer. As a consequence, the modulation of KBs and SIRT1 is considered a promising therapeutic option for many diseases. The direct regulation of gene expression can occur in vivo through histone modifications mediated by both SIRT1 and KBs during fasting or low-carbohydrate diets, and dietary metabolites may contribute to epigenetic regulation, leading to greater genomic plasticity. In this review, we provide an updated overview of the epigenetic interactions between KBs and SIRT1, with a particular glance at their central, synergistic roles for metabolic health.

引用

页数：18

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