The Molecular Physiology of Uric Acid Homeostasis

被引：386

作者：

Mandal, Asim K. ^{[1
]}

Mount, David B.

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Div Renal, Sch Med, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 77 | 2015年 / 77卷

关键词：

uric acid; hyperuricemia; URAT1; SLC2A9; ABCG2; BRUSH-BORDER MEMBRANE; GENOME-WIDE ASSOCIATION; P-AMINOHIPPURATE TRANSPORT; ORGANIC ANION TRANSPORTER-2; URATE EFFLUX TRANSPORTER; KIDNEY PROXIMAL TUBULES; US GENERAL-POPULATION; RENAL EXCRETION; SERUM URATE; CARDIOVASCULAR-DISEASE;

D O I：

10.1146/annurev-physiol-021113-170343

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Serum uric acid is determined by production and the net balance of reabsorption or secretion by the kidney and intestine. A detailed understanding of epithelial absorption and secretion of uric acid has recently emerged, aided in particular by the results of genome-wide association studies of hyperuricemia. Novel genetic and regulatory networks with effects on uric acid homeostasis have also emerged. These developments promise to lead to a new understanding of the various diseases associated with hyperuricemia and to novel, targeted therapies for hyperuricemia.

引用

页码：323 / 345

页数：23

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