Host cellular signaling induced by influenza virus

被引：18
作者：
Dai XinXian [1 ]
Zhang LiShu [1 ]
Hong Tao [2 ]
机构：
[1] Beijing Jiaotong Univ, Sch Sci, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China
[2] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 100052, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2011年 / 54卷 / 01期
关键词：
influenza virus; virus-host interaction; signal transduction; NF-KAPPA-B; DOUBLE-STRANDED-RNA; ACTIVATED PROTEIN-KINASE; TRANSLATION INITIATION-FACTOR; BRONCHIAL EPITHELIAL-CELLS; INNATE IMMUNE-RESPONSE; TOLL-LIKE-RECEPTORS; INDUCIBLE GENE-I; A-VIRUS; NS1; PROTEIN;
D O I：
10.1007/s11427-010-4116-z
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A wide range of host cellular signal transduction pathways can be stimulated by influenza virus infection. Some of these signal transduction pathways induce the host cell's innate immune response against influenza virus, while others are essential for efficient influenza virus replication. This review examines the cellular signaling induced by influenza virus infection in host cells, including host pattern recognition receptor (PRR)-related signaling, protein kinase C (PKC), Raf/MEK/ERK and phosphatidy-linositol-3-kinase (PI3K)/Akt signaling, and the corresponding effects on the host cell and/or virus, such as recognition of virus by the host cell, viral absorption and entry, viral ribonucleoprotein (vRNP) export, translation control of cellular and viral proteins, and virus-induced cell apoptosis. Research into influenza virus-induced cell signaling promotes a clearer understanding of influenza virus-host interactions and assists in the identification of novel antiviral targets and antiviral strategies.
引用
收藏
页码：68 / 74
页数：7
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