Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia

被引：10

作者：

Stauffer, P. R. ^{[1
]}

Craciunescu, O. I. ^{[1
]}

Maccarini, P. F. ^{[1
]}

Wyatt, C. ^{[1
]}

Arunachalam, K. ^{[1
]}

Arabe, O. ^{[1
]}

Stakhursky, V. ^{[1
]}

Soher, B. ^{[2
]}

MacFall, J. R. ^{[2
]}

Li, Z. ^{[3
]}

Joines, W. T. ^{[3
]}

Rangarao, S. ^{[1
]}

Cheng, K. S. ^{[1
]}

Das, S. K. ^{[1
]}

Martins, C. D. ^{[1
]}

Charles, C. ^{[2
]}

Dewhirst, M. W. ^{[1
]}

Wong, T. ^{[2
]}

Jones, E. ^{[1
]}

Vujaskovic, Z. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Radiol Dept, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Elect Engn Dept, Durham, NC 27710 USA

来源：

ENERGY-BASED TREATMENT OF TISSUE AND ASSESSMENT V | 2009年 / 7181卷

关键词：

Non-Invasive Thermometry; Magnetic Resonance Temperature Imaging; Deep Hyperthermia; Radiofrequency Phased Array Heating;

D O I：

10.1117/12.812188

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance thermal imaging (MRTI) is used to measure 2D temperature rise distributions in four cross sections of large extremity soft tissue sarcomas during hyperthermia treatments. Novel hardware and software techniques are described which improve the signal to noise ratio of MR images, minimize motion artifact from circulating coupling fluids, and provide accurate high resolution volumetric thermal dosimetry. For the first 10 extremity sarcoma patients, the mean difference between MRTI region of interest and adjacent interstitial point measurements during the period of steady state temperature was 0.85 degrees C. With 1min temporal resolution of measurements in four image planes, this non-invasive MRTI approach has demonstrated its utility for accurate monitoring and realtime steering of heat into tumors at depth in the body.

引用

页数：12

共 8 条

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