Treatment of Nonmotor Symptoms in Parkinson's Disease

被引：14

作者：

Sauerbier, Anna ^{[1
,2
]}

Cova, Ilaria ^{[3
]}

Rosa-Grilo, Miguel ^{[1
,2
]}

Taddei, Raquel N. ^{[1
,2
]}

Mischley, Laurie K. ^{[4
,5
,6
]}

Chaudhuri, K. Ray ^{[2
,7
,8
,9
,10
]}

机构：

[1] Kings Coll London, London, England

[2] Kings Coll Hosp London, London, England

[3] Univ Milan, Ctr Res & Treatment Cognit Dysfunct, Inst Clin Neurol, Luigi Sacco Hosp, Milan, Italy

[4] Bastyr Univ, Res Inst, Kenmore, WA USA

[5] UW Grad Program Nutr Sci, Seattle, WA USA

[6] Univ Washington UW, Seattle, WA USA

[7] Kings Coll London, Natl Parkinson Fdn Int Ctr Excellence, London, England

[8] Kings Coll London, Maurice Wohl Clin Neurosci Inst, London, England

[9] South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res NIHR, Mental Hlth Biomed Res Ctr BRC, London, England

[10] South London & Maudsley NHS Fdn Trust, Dementia Unit, London, England

来源：

PARKINSON'S DISEASE | 2017年 / 132卷

关键词：

DEEP BRAIN-STIMULATION; NEUROGENIC ORTHOSTATIC HYPOTENSION; COGNITIVE-BEHAVIORAL THERAPY; DAYTIME SLEEPINESS; DOUBLE-BLIND; DEPRESSIVE SYMPTOMS; IMPROVES SLEEP; CLINICAL-TRIAL; OPEN-LABEL; MOTOR;

D O I：

10.1016/bs.irn.2017.03.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nonmotor symptoms (NMS) are integral to Parkinson's disease (PD) and the management can often be challenging. In spite of the growing evidence that NMS have a key impact on the quality of life of patients and caregivers, most clinical trials still focus on motor symptoms as primary outcomes. As a consequence strong evidence-based treatment recommendations for NMS occurring in PD are spare. In this chapter, the current data addressing the treatment of major NMS such as sleep, cognitive and autonomic dysfunction, and depression and anxiety are described.

引用

页码：361 / 379

页数：19

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