Cobalt(III)-Catalyzed C-C Coupling of Arenes with 7-Oxabenzonorbornadiene and 2-Vinyloxirane via C-H Activation

被引：102

作者：

Kong, Lingheng ^{[1
,2
]}

Yu, Songjie ^{[1
]}

Tang, Guodong ^{[1
]}

Wang, He ^{[1
]}

Zhou, Xukai ^{[1
,2
]}

Li, Xingwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 15期

基金：

中国国家自然科学基金;

关键词：

N-TYPE REACTIONS; ALLYLIC ALCOHOLS; BOND ACTIVATION; MULTISUBSTITUTED ISOQUINOLINES; INTERNAL ALKYNES; INDOLE SYNTHESIS; ALLYLATION; FUNCTIONALIZATION; AMIDATION; ACCESS;

D O I：

10.1021/acs.orglett.6b01806

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Co(III)-catalyzed mild C-C couplings of arenes with strained rings such as 7-oxabenzonorbomadienes and 2-vinyloxirane have been realized. The transformation is proposed to undergo ortho C-H activation, olefin insertion, and subsequent beta-oxygen elimination. A broad range of synthetically useful functional groups are compatible, thus providing a new entry to access diversely 2-functionalized indoles.

引用

页码：3802 / 3805

页数：4