SYNTHESIS AND ANTIVIRAL EVALUATION OF 1,3-DIMETHYL-6-(1H-1,2,3-TRIAZOL-1-YL)PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES

被引：14
|
作者：
El-Etrawy, A. Sh. [2 ]
Abdel-Rahman, A. A. -H. [1 ]
机构：
[1] Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm, Egypt
[2] Misr Univ Sci & Technol, Dept Organ Chem, Coll Pharm, 6th October City, Egypt
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2010年 / 46卷 / 09期
关键词：
pyrimidine derivatives; 1,2,3-triazoles; anti hepatitis A virus; cycloaddition; AZIDES;
D O I：
10.1007/s10593-010-0633-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some 6-(1H-1,2,3-triazol-1-yl) pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.
引用
收藏
页码：1105 / 1108
页数：4
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