Cp*CoIII-Catalyzed C(sp3)-H Bond Amidation of 8-Methylquinoline

被引：128
作者：
Barsu, Nagaraju [1 ]
Rahman, Md Atiur [1 ]
Sen, Malay [1 ]
Sundararaju, Basker [1 ]
机构：
[1] Indian Inst Technol Kanpur, Dept Chem, Fine Chem Lab, Kanpur 208016, Uttar Pradesh, India
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 27期
关键词：
amidation; cobalt; quinoline; sp(3) C-H activation; H AMIDATION; INTERMOLECULAR AMIDATION; COBALT(III)-CATALYZED ARYL; INDOLE SYNTHESIS; CARBON-CARBON; C-SP3-H BONDS; ACTIVATION; FUNCTIONALIZATION; AMINATION; ALKYNES;
D O I：
10.1002/chem.201601597
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and external oxidant-free, Cp*Co-III-catalyzed C(sp(3))-H bond amidation of 8-methylquinoline, using oxazolone as an efficient amidating agent, is reported for the first time under mild conditions. The reaction is selective and tolerates a variety of functional groups. Based on previous reports and experimental results, the deprotonation pathway proceeds through an external base-assisted concerted metalation and deprotonation process.
引用
收藏
页码：9135 / 9138
页数：4
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