Puberty suppression in transgender children and adolescents

被引：85

作者：

Mahfouda, Simone ^{[1
,2
,3
]}

Moore, Julia K. ^{[1
,2
,4
]}

Siafarikas, Aris ^{[3
,5
,6
,7
]}

Zepf, Florian D. ^{[1
,2
,3
,8
]}

Lin, Ashleigh ^{[3
]}

机构：

[1] Univ Western Australia, Ctr & Discipline Child & Adolescent Psychiat Psyc, Div Psychiat & Clin Neurosci, Perth, WA 6009, Australia

[2] Univ Western Australia, Div Paediat & Child Hlth, Sch Med, Fac Hlth & Med Sci, Perth, WA, Australia

[3] Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia

[4] Child & Adolescent Hlth Serv, Gender Divers Serv, Acute Child & Adolescent Mental Hlth Serv, Perth, WA, Australia

[5] Princess Margaret Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia

[6] Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Div Paediat & Child Hlth, Perth, WA, Australia

[7] Univ Notre Dame, Inst Hlth Res, Fremantle, WA, Australia

[8] Dept Hlth Western Australia, Specialised Child & Adolescent Mental Hlth Serv, Perth, WA, Australia

来源：

LANCET DIABETES & ENDOCRINOLOGY | 2017年 / 5卷 / 10期

基金：

英国医学研究理事会;

关键词：

GONADOTROPIN-RELEASING-HORMONE; GENDER IDENTITY DISORDER; CHILDHOOD DIAGNOSTIC CATEGORY; CENTRAL PRECOCIOUS PUBERTY; QUALITY-OF-LIFE; FOLLOW-UP; SEX REASSIGNMENT; CLINICAL MANAGEMENT; AGONIST TREATMENT; MEDICAL-TREATMENT;

D O I：

10.1016/S2213-8587(17)30099-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The World Professional Association for Transgender Health's standards of care recommend suspending puberty, preferably with the use of gonadotropin-releasing hormone agonists, in certain gender non-conforming minors (aged under 18 years) who have undergone a psychiatric assessment and have reached at least Tanner stage II of puberty. This approach seeks to lessen the discordance between assigned natal sex and gender identity by temporarily halting the development of secondary sexual characteristics, essentially widening the temporal window for gender clarification. Despite promising preliminary evidence on the clinical utility of this approach, there is a dearth of research to inform evidence-based practice. In view of these challenges, we review the available empirical evidence on the cognitive, physical, and surgical implications of puberty suppression in gender-incongruent children and adolescents. We also explore the historical underpinnings and clinical impetus for suspending puberty in this population, and propose key research priorities.

引用

页码：816 / 826

页数：11

共 96 条

[1] Effects of combined sex hormone replacement therapy on small artery biomechanics in pharmacologically ovariectomized rats [J].