Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein

被引：56

作者：

Robotta, Marta ^{[4
]}

Braun, Patrick ^{[4
]}

van Rooijen, Bart ^{[1
,2
]}

Subramaniam, Vinod ^{[1
,2
]}

Huber, Martina ^{[3
]}

Drescher, Malte ^{[4
]}

机构：

[1] Univ Twente, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands

[2] Univ Twente, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands

[3] Leiden Univ, Leiden Inst Phys, NL-2300 RA Leiden, Netherlands

[4] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

来源：

CHEMPHYSCHEM | 2011年 / 12卷 / 02期

关键词：

electron paramagnetic resonance; membranes; proteins; site-directed spin labeling; vesicles; DYNAMICS; BINDING; PROTEIN; VESICLES; DISEASE;

D O I：

10.1002/cphc.201000815

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Good luck! The physiologically relevant conformation of membrane-bound α-Synuclein (αS) can be either a horseshoe or an extended helix structure. Experimental data obtained by site-directed spin labeling in combination with pulsed electron paramagnetic resonance provide compelling evidence of the coexistence of the horseshoe structure and an extended helix of αS bound to a membrane surface, and potentially resolve the debate on the structure of membrane-bound αS. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：267 / 269

页数：3