Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein

被引：56
|
作者：
Robotta, Marta [4 ]
Braun, Patrick [4 ]
van Rooijen, Bart [1 ,2 ]
Subramaniam, Vinod [1 ,2 ]
Huber, Martina [3 ]
Drescher, Malte [4 ]
机构：
[1] Univ Twente, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands
[2] Univ Twente, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands
[3] Leiden Univ, Leiden Inst Phys, NL-2300 RA Leiden, Netherlands
[4] Univ Konstanz, Dept Chem, D-78457 Constance, Germany
来源：
CHEMPHYSCHEM | 2011年 / 12卷 / 02期
关键词：
electron paramagnetic resonance; membranes; proteins; site-directed spin labeling; vesicles; DYNAMICS; BINDING; PROTEIN; VESICLES; DISEASE;
D O I：
10.1002/cphc.201000815
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Good luck! The physiologically relevant conformation of membrane-bound α-Synuclein (αS) can be either a horseshoe or an extended helix structure. Experimental data obtained by site-directed spin labeling in combination with pulsed electron paramagnetic resonance provide compelling evidence of the coexistence of the horseshoe structure and an extended helix of αS bound to a membrane surface, and potentially resolve the debate on the structure of membrane-bound αS. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：267 / 269
页数：3
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