Toxic effects of formaldehyde and the protective effect of docosahexaenoic acid in Drosophila

被引：5
作者：
Hua, Yanli [1 ]
Ma, Chao [1 ]
Huang, Shuyi [1 ]
Wang, Ruomeng [1 ]
Chen, Jian [1 ]
Guo, Qing [1 ]
Zhou, Jiaojiao [1 ]
Zhu, Hemin [1 ]
Li, Wenjie [1 ]
机构：
[1] Soochow Univ, Med Coll, Dept Human Anat, 199 Ren Ai Rd, Suzhou 215123, Peoples R China
来源：
TRANSLATIONAL NEUROSCIENCE | 2021年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
formaldehyde; docosahexaenoic acid; neuro-protection; EXPOSURE; MEMORY; OMEGA-3-FATTY-ACIDS; SUPPLEMENTATION; MUTATIONS; RABBITS; SYSTEM; BRAIN; DHA;
D O I：
10.1515/tnsci-2020-0186
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Formaldehyde (FA) is a commercially impor-tant chemical applied in industry and scientific research. However, FA has a distinct impact on learning and memory. Although the mechanisms of FA toxicity have been well studied, additional research is required to establish the mechanisms of neuroprotection in cases of FA exposure. Docosahexaenoic acid (DHA) is a polyun-saturated fatty acid with a variety of health benefits, including the enhancement of learning and memory. In this study, we investigated the neuroprotective effects of DHA in Drosophila melanogaster that had ingested FA. Our data suggested that DHA enhanced reproductive pro-cesses, leading to an increase in the number of eggs, larvae, and adults. Surprisingly, we found that DHA had a mild protective effect against FA-induced impair-ments in learning and memory.
引用
收藏
页码：351 / 361
页数：11
相关论文
共 49 条
[1]   A BDNF AUTOCRINE LOOP IN ADULT SENSORY NEURONS PREVENTS CELL DEATH [J].
ACHESON, A ;
CONOVER, JC ;
FANDL, JP ;
DECHIARA, TM ;
RUSSELL, M ;
THADANI, A ;
SQUINTO, SP ;
YANCOPOULOS, GD ;
LINDSAY, RM .
NATURE, 1995, 374 (6521) :450-453
[2]   Sensory mechanisms controlling the timing of larval developmental and behavioral transitions require the Drosophila DEG/ENaC subunit, Pickpocket1 [J].
Ainsley, Joshua A. ;
Kim, Myung Jun ;
Wegman, Lauren J. ;
Pettus, Janette M. ;
Johnson, Wayne A. .
DEVELOPMENTAL BIOLOGY, 2008, 322 (01) :46-55
[3]   Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature [J].
Allegra, Alessandro ;
Spatari, Giovanna ;
Mattioli, Stefano ;
Curti, Stefania ;
Innao, Vanessa ;
Ettari, Roberta ;
Allegra, Andrea Gaetano ;
Giorgianni, Concetto ;
Gangemi, Sebastiano ;
Musolino, Caterina .
MEDICINA-LITHUANIA, 2019, 55 (10)
[4]   Central nervous system toxicity after acute oral formaldehyde exposure in rabbits: An experimental study [J].
Arici, S. ;
Karaman, S. ;
Dogru, S. ;
Cayli, S. ;
Arici, A. ;
Suren, M. ;
Karaman, T. ;
Kaya, Z. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2014, 33 (11) :1141-1149
[5]   Toxic effect of formaldehyde on the respiratory organs of rabbits: A light and electron microscopic study [J].
Bansal, Neelam ;
Uppal, Varinder ;
Pathak, Devendra .
TOXICOLOGY AND INDUSTRIAL HEALTH, 2011, 27 (06) :563-569
[6]   Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development [J].
Bartkowska, Katarzyna ;
Paquin, Annie ;
Gauthier, Andree S. ;
Kaplan, David R. ;
Miller, Freda D. .
DEVELOPMENT, 2007, 134 (24) :4369-4380
[7]   Omega-3 supplementation improves cognition and modifies brain activation in young adults [J].
Bauer, Isabelle ;
Hughes, Matthew ;
Rowsell, Renee ;
Cockerell, Robyn ;
Pipingas, Andrew ;
Crewther, Sheila ;
Crewther, David .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2014, 29 (02) :133-144
[8]   Omega 3 fatty acids on child growth, visual acuity and neurodevelopment [J].
Campoy, Cristina ;
Victoria Escolano-Margarit, Ma ;
Anjos, Tania ;
Szajewska, Hania ;
Uauy, Ricardo .
BRITISH JOURNAL OF NUTRITION, 2012, 107 :S85-S106
[9]   Dietary DHA and health: cognitive function ageing [J].
Cardoso, Carlos ;
Afonso, Claudia ;
Bandarra, Narcisa M. .
NUTRITION RESEARCH REVIEWS, 2016, 29 (02) :281-294
[10]   A Behavioral Odor Similarity "Space" in Larval Drosophila [J].
Chen, Yi-chun ;
Mishra, Dushyant ;
Schmitt, Linda ;
Schmuker, Michael ;
Gerber, Bertram .
CHEMICAL SENSES, 2011, 36 (03) :237-249
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