Mesostructured silica and aluminosilicate carriers for oxytetracycline delivery systems

被引：16

作者：

Berger, D. ^{[1
]}

Nastase, S. ^{[1
]}

Mitran, R. A. ^{[1
]}

Petrescu, M. ^{[1
]}

Vasile, E. ^{[2
]}

Matei, C. ^{[1
]}

Negreanu-Pirjol, T. ^{[3
]}

机构：

[1] Univ Politehn Bucuresti, Dept Inorgan Chem Phys Chem & Electrochem, Polizu St 1-7, Bucharest 011061, Romania

[2] Univ Politehn Bucuresti, Dept Oxide Mat Sci & Engn, Polizu St 1-7, Bucharest 011061, Romania

[3] Ovidius Univ Constanta, Fac Pharm, Aleea Univ 1, Constanta 900470, Romania

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2016年 / 510卷 / 02期

关键词：

Oxytetracycline; Drug delivery system; MCM-41; Aluminosilicates; Staphylococcus aureus clinical strains; DRUG-DELIVERY; MESOPOROUS SILICA; IN-VITRO; NANOPARTICLES; PROPERTY;

D O I：

10.1016/j.ijpharm.2016.02.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxytetracycline delivery systems containing various MCM-type silica and aluminosilicate with different antibiotic content were developed in order to establish the influence of the support structural and textural properties and aluminum content on the drug release profile. The antibiotic molecules were loaded into the support mesochannels by incipient wetness impregnation method using a drug concentrated aqueous solution. The carriers and drug-loaded materials were investigated by small-and wide-angle XRD, FTIR spectroscopy, TEM and N-2 adsorption-desorption isotherms. Faster release kinetics of oxytetracycline from uncalcined silica and aluminosilicate supports was observed, whereas higher drug content led to lower delivery rate. The presence of aluminum into the silica network also slowed down the release rate. The antimicrobial assays performed on Staphylococcus aureus clinical isolates showed that the oxytetracycline-loaded materials containing MCM-41-type mesoporous silica or aluminosilicate carriers inhibited the bacterial development. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：524 / 531

页数：8

共 27 条

[1]

[Anonymous], 2012, M02A11 CLSI

[2] Influence of structural, textural and surface properties of mesostructured silica and aluminosilicate carriers on aminoglycoside uptake and in vitro delivery [J].

Berger, Daniela ;

Bajenaru, Laura ;

Nastase, Silviu ;

Mitran, Raul-Augustin ;

Munteanu, Cornel ;

Matei, Cristian .

MICROPOROUS AND MESOPOROUS MATERIALS, 2015, 206 :150-160

[3] Transfer of oxytetracycline from swine manure to three different aquatic plants: Implications for human exposure [J].

Boonsaner, Maliwan ;

Hawker, Darryl W. .

CHEMOSPHERE, 2015, 122 :176-182

[4] Evaluation of food chain transfer of the antibiotic oxytetracycline and human risk assessment [J].

Boonsaner, Maliwan ;

Hawker, Darryl W. .

CHEMOSPHERE, 2013, 93 (06) :1009-1014

[5] Drug delivery devices based on mesoporous silicate [J].

Cavallaro, G ;

Pierro, P ;

Palumbo, FS ;

Testa, F ;

Pasqua, L ;

Aiello, R .

DRUG DELIVERY, 2004, 11 (01) :41-46

[6] Inclusion of ibuprofen in mesoporous templated silica:: drug loading and release property [J].

Charnay, C ;

Bégu, S ;

Tourné-Péteilh, C ;

Nicole, L ;

Lerner, DA ;

Devoisselle, JM .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (03) :533-540

[7]

Doi AM, 2000, J AQUAT ANIM HEALTH, V12, P246, DOI 10.1577/1548-8667(2000)012<0246:TKOODI>2.0.CO

[8]

[9]

Dorneanu O., 2006, J PREV MED, V14, P66

[10]

George S., 2001, Infrared Characteristic Group Frequencies, V3rd

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