Assessment of lymph nodes and prostate status with early dynamic curves PET/CT 18F-choline in prostate cancer

Aim. - Analyse early dynamic F-18-Choline (FCH) PET/CT acquisitions to define lymph nodes and prostate pathological status. Patients and methods. - Retrospective analysis was performed on 39 patients for initial staging (n = 18) or after initial treatment (n = 21). Patients underwent 10 minutes dynamic acquisitions centered on pelvis, after injection of 3-4 MBq/kg of FCH. Whole body images were performed about 1 hour after injection and were acquired on PET/CT GE Discovery LS (GE-LS) or Siemens Biograph mCT (mCT). Maximum SUVaccording to time was measured on lymph nodes and prostate lesions. The status of each lesion was based on histological results or patient follow-up (> 6 months). Results. - The median PSA was 8.46 ng/mL and the median Gleason 3+4. Ninety-two lesions (43 lymph nodes and 49 prostate lesions) were analyzed, including 63 malignant lesions. In early dynamic acquisitions, the maximum SUV was significantly higher, respectively on mCT and GE-LS, in positive lymph nodes (P < 0.001, P = 0.007) and prostate (P = 0.001, P = 0.02). ROC curves showed for lymph nodes acquired on mCT, a trend to better numbers of sensitivity and specificity for early acquisitions, compared with late acquisitions. Conclusion. - Assessment of lymph nodes and prostate pathological status with early dynamic curves PET/CT FCH was interestingly possible in a disease where proofs of malignancy are difficult to obtain. (C) 2015 Elsevier Masson SAS. All rights reserved.