The neurobiology of schizophrenia: new leads and avenues for treatment

被引：15

作者：

Bray, Nicholas J. ^{[1
]}

Leweke, F. Markus ^{[3
]}

Kapur, Shitij ^{[2
]}

Meyer-Lindenberg, Andreas ^{[3
]}

机构：

[1] Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England

[2] Kings Coll London, Inst Psychiat, Dept Psychol Med, London WC2R 2LS, England

[3] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-6800 Mannheim, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2010年 / 20卷 / 06期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; BIPOLAR DISORDER; COMMON VARIANTS; GENE-EXPRESSION; DISC1; BRAIN; INHIBITORS; RISK; CONNECTIVITY; METAANALYSIS;

D O I：

10.1016/j.conb.2010.09.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent large-scale genetic studies have provided robust evidence implicating several novel susceptibility genes for schizophrenia. These include ZNF804A, TCF4 and NRGN, which contain common variants that weakly increase schizophrenia susceptibility, and NRXN1, in which rare copy number variants have a greater impact on schizophrenia risk. Investigation of these and other substantiated susceptibility genes are providing valuable insight into the primary neurobiological mechanisms underlying schizophrenia, which may lead to novel therapeutic interventions for the disorder. In the meantime, several novel pharmacological strategies, including activation of mGluRs, elevation of synaptic glycine and inhibition of phosphodiesterase 10A, have recently shown promise for the treatment of schizophrenia in clinical trials.

引用

页码：810 / 815

页数：6

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