Axonal Damage and its Significance for the Concept of Neurodegeneration in Multiple Sclerosis

被引：3

作者：

Recks, M. S. ^{[1
]}

Bader, J. ^{[1
]}

Kaiser, C. C. ^{[2
]}

Schroeter, M. ^{[2
]}

Fink, G. R. ^{[2
]}

Addicks, K. ^{[1
]}

Kuerten, S. ^{[1
]}

机构：

[1] Univ Cologne, Inst Anat 1, D-50931 Cologne, Germany

[2] Univ Cologne, Neurol Klin & Poliklin, D-50931 Cologne, Germany

来源：

FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE | 2011年 / 79卷 / 03期

关键词：

axonal damage; demyelination; EAE; inflammation; MS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CYTOTOXIC T-LYMPHOCYTES; APPEARING WHITE-MATTER; AUTOIMMUNE ENCEPHALOMYELITIS; MONOCLONAL-ANTIBODY; DEMYELINATION; LESIONS; INJURY; CNS; TRANSPORT;

D O I：

10.1055/s-0029-1246014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In spite of tremendous scientific effort, the mechanisms underlying multiple sclerosis (MS) still remain to be elucidated. The prevalent pathogenetic concept adheres to the assumption of a strict hierarchical sequence of the triad inflammation, demyelination and axonal damage. However, recent studies have provided evidence that axonal pathology can occur independently of inflammation and demyelination. The present article critically re-evaluates the traditional paradigm of MS pathology. Potential cellular, humoral and metabolic mechanisms of axonal pathology are delineated and the development of isolated axonal damage is assessed. A better understanding of the pathological processes underlying MS is likely to result in an improvement of current therapeutic strategies. These should not only target the inflammatory, but also the neurodegenerative component of the disease.

引用

页码：161 / 170

页数：10

共 62 条

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