Synthesis and biological activities of 4-alkyl/aryl-2-fluoroaryl-1H,1,5-benzodiazepines

被引：0
|
作者：
Pathak, VN [1 ]
Joshi, R [1 ]
Tiwari, R [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 10卷 / 03期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of fluorinated 4-alkyl/aryl-2-fluoroaryl-1H-1,5-benzodiazepines (3a-3o) were prepared by treating appropriate fluorinated 1,3-diketone with o-phenylenediamine. These Compounds (3a-3o) were isolated as their monohydrochloride/monoperchlorate or as a free base and characterized by their analytical and spectral data. Some of these 4-alkyl/aryl-2-fluoroaryl-1H-1,5-benzodiazepines have exhibited excellent gastric acid secretion pylorus ligation, passive cutaneous anaphylaxis and parasitological activities in rats and monkeys.
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页码：171 / 174
页数：4
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