MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE

被引：9
作者：
Wang, Hao [1 ,4 ]
Song, Hong-rui [2 ]
Cui, Yong [3 ]
Deng, Ying-jie [1 ]
Chen, Xue-si [4 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
[3] Shenyang Pharmaceut Univ, Sch Life Sci & Pharmacol, Shenyang 110016, Peoples R China
[4] Changchun Inst Appl Chem, Chinese Acad Sci, State Key Lab Polymer Chem & Phys, Changchun 130022, Peoples R China
来源：
CHINESE JOURNAL OF POLYMER SCIENCE | 2011年 / 29卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Medicated fiber; Electrospinning; Drug release; Poly(ethylene glycol); Polylactide; Magnolol; Proteinase K; BIOMEDICAL APPLICATIONS; BLOCK-COPOLYMERS; FIBERS; GLYCOL); ACID);
D O I：
10.1007/s10118-011-1024-z
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly(ethylene glycol) blocked poly(L-lactide). Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry. According to in vitro drug release investigation by high performance liquid chromatography, it was found that fibers with 10%, 20% and 30% drug entrapped respect to polymer (mass ratio) presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K. The reason may be that fibers with 10% drug entrapped was more easily affected by enzyme while, to some degree, magnolol in fibers with 20% and 30% entrapped prevented polymer from being degraded by enzyme.
引用
收藏
页码：173 / 179
页数：7
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