Polymerizing Like Mussels Do: Toward Synthetic Mussel Foot Proteins and Resistant Glues

被引：43

作者：

Horsch, Justus ^{[1
]}

Wilke, Patrick ^{[1
]}

Pretzler, Matthias ^{[2
]}

Seuss, Maximilian ^{[3
]}

Melnyk, Inga ^{[3
]}

Remmler, Dario ^{[1
]}

Fery, Andreas ^{[3
,4
]}

Rompel, Annette ^{[2
]}

Boerner, Hans G. ^{[1
]}

机构：

[1] Humboldt Univ, Lab Organ Synth Funct Syst, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany

[2] Univ Wien, Fak Chem, Inst Biophys Chem, Althanstr 14, A-1090 Vienna, Austria

[3] Leibniz Inst Polymerforsch Dresden eV, Inst Phys Chem & Polymer Phys, Hohe Str 6, D-01069 Dresden, Germany

[4] Tech Univ Dresden, Chair Phys Chem Polymer Mat, Hohe Str 6, D-01069 Dresden, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 48期

基金：

奥地利科学基金会;

关键词：

adhesives; enzyme-induced polymerization; mussel glue; synthetic protein mimics; tyrosinase activation; CROSS-LINKING; ADHESIVE; ENZYME; STRATEGY;

D O I：

10.1002/anie.201809587

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel strategy to generate adhesive protein analogues by enzyme-induced polymerization of peptides is reported. Peptide polymerization relies on tyrosinase oxidation of tyrosine residues to Dopaquinones, which rapidly form cysteinyldopa-moieties with free thiols from cysteine residues, thereby linking unimers and generating adhesive polymers. The resulting artificial protein analogues show strong adsorption to different surfaces, even resisting hypersaline condition. Remarkable adhesion energies of up to 10.9 ml m(-2) are found in single adhesion events and average values are superior to those reported for mussel Pot proteins that constitute the gluing interfaces.

引用

页码：15728 / 15732

页数：5

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