Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy

被引:137
作者
Guan, Qingqing [1 ]
Guo, Ruomi [2 ]
Huang, Shihui [3 ]
Zhang, Fan [1 ]
Liu, Jie [1 ]
Wang, Zhiyong [3 ]
Yang, Xi [1 ]
Shuai, Xintao [3 ]
Cao, Zhong [1 ]
机构
[1] Sun Yat Sen Univ, Sch Biomed Engn, Guangdong Prov Key Lab Sensor Technol & Biomed In, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Radiol, Guangzhou 510630, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sch Mat Sci & Engn, Minist Educ, PCFM Lab, Guangzhou 510275, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Ferroptosis; Mesoporous polydopamine; Sorafenib; Cancer theranostics; DRUG-DELIVERY; IRON; RESISTANCE; PLATFORM; CELLS;
D O I
10.1016/j.jconrel.2020.01.048
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Iron-based nanomaterials as the main ferroptosis-inducing platforms are more promising because iron itself is a key component in the Fenton reaction to produce ROS. However, the Fe dose needs to be very high in order to induce ferroptosis-based cancer treatment using the SPIO NPs. Therefore, it is still of great challenge to enhance the efficacy of ferroptosis-based cancer therapy by associating the iron-based nanomaterials with other components and therapeutic modalities. In this study, sorafenib (SRF) and ultrasmall SPIO nanoparticles were loaded into the mesopores and onto the surface of MPDA NPs to form SRF@MPDA-SPIO nanoparticles. SPIO loading endowed the system with iron-supply for ferroptosis and made the system MRI-visible. Meanwhile, SRF was able to induce ferroptosis in cancer cells with lower Fe dose. Furthermore, the heat generated by MPDA NPs upon laser irradiation offered a moderate PTT to boost the ferroptosis effect. The SRF@MPDA-SPIO exhibited bio-compatibility highly desirable for in vivo application and superior anticancer therapy via the combination of ferroptosis and photothermal therapy.
引用
收藏
页码:392 / 403
页数:12
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