Is there a place for angiotensin receptor-neprilysin inhibitors in the treatment of heart failure patients after heart transplantation?

被引：3
作者：
Gulin, Dario [1 ,2 ]
Planinic, Zrinka [1 ]
Habek, Jasna Cerkez [1 ,3 ]
Sikic, Jozica [1 ,2 ]
机构：
[1] Univ Hosp Sveti Duh, Dept Cardiovasc Dis, Sveti Duh 64, Zagreb 10000, Croatia
[2] Univ Zagreb, Sch Med, Zagreb, Croatia
[3] Croatian Catholic Univ, Zagreb, Croatia
来源：
INDIAN JOURNAL OF PHARMACOLOGY | 2019年 / 51卷 / 06期
关键词：
Heart failure; heart transplantation; sacubitril; valsartan; WORKING FORMULATION; NOMENCLATURE; DIAGNOSIS;
D O I：
10.4103/ijp.IJP_562_18
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We present a case report of a heart failure patient after heart transplantation due to end-stage ischemic cardiomyopathy with significant clinical and echocardiographic improvement 3 months after the introduction of sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor. This new class of drugs is proved to be beneficial in heart failure patients, especially with reduced ejection fraction (HFrEF), but they have not yet been used in heart failure patients after heart transplantation. We believe that the increase of left ventricular systolic function, improvement of global longitudinal strain, and reduction of pulmonary hypertension with consequent clinical recovery in our patient may have been caused by sacubitril/valsartan.
引用
收藏
页码：413 / 415
页数：3
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