The Genomic Signature of Breast Cancer Prevention

被引：13
作者：
Russo, Jose [1 ]
Santucci-Pereira, Julia [1 ]
Russo, Irma H. [1 ]
机构：
[1] Temple Univ Hlth Syst, Fox Chase Canc Ctr, Irma H Russo MD Breast Canc Res Lab, Philadelphia, PA 19111 USA
来源：
GENES | 2014年 / 5卷 / 01期
关键词：
normal breast; breast cancer; genomic signature; prevention; pregnancy; splicing mechanisms; methylation; chromatin remodeling; Lnc-RNA; beta-catenin; CATENIN DESTRUCTION COMPLEX; PREGNANCY-INDUCED CHANGES; MAMMARY EPITHELIAL-CELLS; BETA-CATENIN; DUCTAL CARCINOMA; GENE-EXPRESSION; CHORIONIC-GONADOTROPIN; E-CADHERIN; FULL-TERM; GLAND;
D O I：
10.3390/genes5010065
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy. Through the analysis of the genes found to be differentially methylated between women of varying parity, multiple positions at which beta-catenin production and use is inhibited were recognized. The biological importance of the pathways identified in this specific population cannot be sufficiently emphasized because they could represent a safeguard mechanism mediating the protection of the breast conferred by full term pregnancy.
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页码：65 / 83
页数：19
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