Bilateral Symmetry of Visual Function Loss in Cone-Rod Dystrophies

被引：12

作者：

Galli-Resta, Lucia ^{[1
]}

Falsini, Benedetto ^{[2
]}

Rossi, Giuseppe ^{[3
]}

Piccardi, Marco ^{[2
]}

Ziccardi, Lucia ^{[4
]}

Fadda, Antonello ^{[5
]}

Minnella, Angelo ^{[2
]}

Marangoni, Dario ^{[2
]}

Placidi, Giorgio ^{[2
]}

Campagna, Francesca ^{[2
]}

Abed, Edoardo ^{[2
]}

Bertelli, Matteo ^{[6
]}

Zuntinif, Monia ^{[6
]}

Resta, Giovanni ^{[7
]}

机构：

[1] CNR, Ist Neurosci, Pisa, Italy

[2] Catholic Univ, Policlin Gemelli, Inst Ophthalmol, Rome, Italy

[3] CNR, Ist Fisiol Clin, Pisa, Italy

[4] IRCCS, Bietti Fdn, Rome, Italy

[5] Ist Super Sanita, Tecnol & Salute, Rome, Italy

[6] MAGI Lab Med Genet, Rovereto, Italy

[7] CNR, Ist Informat & Telemat, Pisa, Italy

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2016年 / 57卷 / 08期

关键词：

cone dystrophy; interocular; visual acuity; visual function; electroretinography; PIGMENT OPTICAL-DENSITY; STARGARDT DISEASE; GENE-THERAPY; RETINITIS-PIGMENTOSA; PROGRESSIVE CONE; DEGENERATIONS; POPULATION; DISORDERS;

D O I：

10.1167/iovs.15-18313

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To investigate bilateral symmetry of visual impairment in cone-rod dystrophy (CRD) patients and understand the feasibility of clinical trial designs treating one eye and using the untreated eye as an internal control. METHODS. This was a retrospective study of visual function loss measures in 436 CRD patients followed at the Ophthalmology Department of the Catholic University in Rome. Clinical measures considered were best-corrected visual acuity, focal macular cone electroretinogram (fERG), and Ganzfeld cone-mediated and rod-mediated electroretinograms. Interocular agreement in each of these clinical indexes was assessed by t- and Wilcoxon tests for paired samples, structural (Deming) regression analysis, and intraclass correlation. Baseline and follow-up measures were analyzed. A separate analysis was performed on the subset of 61 CRD patients carrying likely disease-causing mutations in the ABCA4 gene. RESULTS. Statistical tests show a very high degree of bilateral symmetry in the extent and progression of visual impairment in the fellow eyes of CRD patients. CONCLUSIONS. These data contribute to a better understanding of CRDs and support the feasibility of clinical trial designs involving unilateral eye treatment with the use of fellow eye as internal control.

引用

页码：3759 / 3768

页数：10

共 34 条

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