Mosquito stage, transmission blocking vaccines for malaria

被引：68

作者：

Saul, Allan ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Biol, NIH, Rockville, MD 20852 USA

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2007年 / 20卷 / 05期

关键词：

gamete; malaria; mosquito; ookinete; plasmodium; transmission blocking vaccine;

D O I：

10.1097/QCO.0b013e3282a95e12

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of review This review highlights progress made in the development of vaccines aimed at the stages of malaria parasites found in mosquitoes that block the transmission of malaria within a community. Recent findings Substantial progress has been made on the production and characterization of the leading candidates P25 and P28 from Plasmodium falciparum and P. vivax. Immunogenicity data have been obtained for P25 in humans that showed significant transmission blocking activity and further advances in formulation should boost this activity, The completion of the malaria genome and ongoing proteomics identified further candidate antigens now entering development. Summary Recent advances increase confidence that a mosquito stage transmission blocking malaria vaccine will be feasible.

引用

页码：476 / 481

页数：6

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