Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp A818

被引：2

作者：

Zhang, Wei ^{[1
,2
]}

Zhao, Baobing ^{[3
]}

Du, Liangcheng ^{[2
]}

Shen, Yuemao ^{[3
]}

机构：

[1] Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Peoples R China

[2] Univ Nebraska Lincoln, Dept Chem, Lincoln, NE 68588 USA

[3] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R China

来源：

MOLECULES | 2017年 / 22卷 / 09期

关键词：

polyketide; mycoepoxydiene; cyclooctadiene; endophtic fungus; cytotoxicity; MYCOEPOXYDIENE; METABOLITES; ANTITUMOR; DEACETYLMYCOEPOXYDIENE; DERIVATIVES; APOPTOSIS; CELLS;

D O I：

10.3390/molecules22091547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure-activity relationship showed that the alpha,beta-unsaturated delta i-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK ( 5'-adenosine monophosphate-activated protein kinase).

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