Inflammatory responses in influenza A virus infection

被引：214
|
作者：
Julkunen, I [1 ]
Melén, K [1 ]
Nyqvist, M [1 ]
Pirhonen, J [1 ]
Sareneva, T [1 ]
Matikainen, S [1 ]
机构：
[1] Natl Publ Hlth Inst, Dept Virol, FIN-00300 Helsinki, Finland
来源：
VACCINE | 2000年 / 19卷
关键词：
influenza A; chemokines; cytokines; transcription factors;
D O I：
10.1016/S0264-410X(00)00275-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the development of antiviral and Th1-type immune response. Influenza A virus-infected respiratory epithelial cells produce limited amounts of chemokines (RANTES, MCP-1, IL-8) and IFN-alpha/beta, whereas monocytes/macrophages readily produce chemokines such as RANTES, MIP-1 alpha, MCP-1, MCP3, IP-10 and cytokines TNF-alpha, IL-1 beta, IL-6, IL-18 and IFN-alpha/beta. The role of influenza A virus-induced inflammatory response in relation to otitis media is being discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：S32 / S37
页数：6
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