Inflammatory responses in influenza A virus infection

被引：215

作者：

Julkunen, I ^{[1
]}

Melén, K ^{[1
]}

Nyqvist, M ^{[1
]}

Pirhonen, J ^{[1
]}

Sareneva, T ^{[1
]}

Matikainen, S ^{[1
]}

机构：

[1] Natl Publ Hlth Inst, Dept Virol, FIN-00300 Helsinki, Finland

来源：

VACCINE | 2000年 / 19卷

关键词：

influenza A; chemokines; cytokines; transcription factors;

D O I：

10.1016/S0264-410X(00)00275-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the development of antiviral and Th1-type immune response. Influenza A virus-infected respiratory epithelial cells produce limited amounts of chemokines (RANTES, MCP-1, IL-8) and IFN-alpha/beta, whereas monocytes/macrophages readily produce chemokines such as RANTES, MIP-1 alpha, MCP-1, MCP3, IP-10 and cytokines TNF-alpha, IL-1 beta, IL-6, IL-18 and IFN-alpha/beta. The role of influenza A virus-induced inflammatory response in relation to otitis media is being discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：S32 / S37

页数：6

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