Glycosylation of glycopeptides:: a comparison of chemoenzymatic and chemical methods

被引：13

作者：

Leimkuhler, C

Chen, Z

Kruger, RG

Oberthür, M

Lu, W

Walsh, CT

Kahne, D

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Biol, Boston, MA 02115 USA

[3] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 02期

关键词：

D O I：

10.1016/j.tetasy.2004.12.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Glycosylating complex molecules remains a major synthetic challenge, making it hard to explore carbohydrate diversity in biologically active glycosylated natural products and their derivatives. In this paper we compare the efficiency of chemical and enzymatic methods for glycosylation of glycopeptides related to vancomycin and describe the parameters that should be considered in designing synthetic approaches to glycosylated natural product derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：599 / 603

页数：5

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