Dendritic Self-Avoidance and Morphological Development of Cerebellar Purkinje Cells

被引：21

作者：

Fujishima, Kazuto ^{[1
]}

Galbraith, Kelly Kawabata ^{[1
,2
]}

Kengaku, Mineko ^{[1
,2
]}

机构：

[1] Kyoto Univ, Inst Integrated Cell Mat Sci WPI iCeMS, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Kyoto 6068501, Japan

来源：

CEREBELLUM | 2018年 / 17卷 / 06期

基金：

日本学术振兴会;

关键词：

Purkinje cell; Dendrite development; Self-avoidance; DROSOPHILA SENSORY NEURONS; THYROID-HORMONE RECEPTOR; GAMMA-PROTOCADHERINS; CLUSTERED PROTOCADHERINS; POSTNATAL-DEVELOPMENT; MOLECULAR-MECHANISMS; GENE-EXPRESSION; IN-VIVO; ALPHA; DYNAMICS;

D O I：

10.1007/s12311-018-0984-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebellar Purkinje cells arborize unique dendrites that exhibit a planar, fan shape. The dendritic branches fill the space of their receptive field with little overlap. This dendritic arrangement is well-suited to form numerous synapses with the afferent parallel fibers of the cerebellar granule cells in a non-redundant manner. Purkinje cell dendritic arbor morphology is achieved by a combination of dynamic local branch growth behaviors, including elongation, branching, and retraction. Impacting these behaviors, the self-avoidance of each branch terminal is essential to form the non-overlapping dendritic configuration. This review outlines recent advances in our understanding of the cellular and molecular mechanisms of dendrite formation during cerebellar Purkinje cell development.

引用

页码：701 / 708

页数：8

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