New therapeutic perspectives in non-alcoholic steatohepatitis

被引：13

作者：

Ampuero, Javier ^{[1
]}

Sanchez-Torrijos, Yolanda ^{[1
]}

Aguilera, Virginia ^{[1
]}

Bellido, Francisco ^{[2
]}

Romero-Gomez, Manuel ^{[1
]}

机构：

[1] Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Unidad Aparato Digest,CIBERehd, Seville, Spain

[2] Hosp Univ Virgen de la Macarena, Seville, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2018年 / 41卷 / 02期

关键词：

Body mass index; Visceral obesity; Obeticolic acid; Peroxisome prolifqrator-activated receptor; Glucagon-like peptide-1 receptor agonists; FATTY LIVER-DISEASE; FARNESOID-X-RECEPTOR; PLACEBO-CONTROLLED TRIAL; AGONIST OBETICHOLIC ACID; Y GASTRIC BYPASS; BARIATRIC SURGERY; OBESE-PATIENTS; GLUCOSE-HOMEOSTASIS; REDUCES FEATURES; RANDOMIZED-TRIAL;

D O I：

10.1016/j.gastrohep.2017.07.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able to improve steatosis, ballooning and fibrosis. Life-style interventions based on Mediterranean diet and increasing physical activity are the first line therapy. In patients with unsuccessful life-style intervention several drugs are under development: agonist PPAR, agonist GLP-1R and agonist FXR together with drugs focussing on inflammation, ballooning, apoptosis and fibrosis. Bariatric surgery or advanced endoscopy are reserved for morbid obese without response to life-style intervention and weighting loss drugs. (C) 2017 Elsevier Espana, S.L.U. All rights reserved.

引用

页码：128 / 142

页数：15

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